Updated September 15, 2012 – Thursday night players removed from Week 2 rankings
RB Rankings
| Rank | Player | Team | Opponent |
| 1 | Arian Foster | HOU | at JAC |
| 2 | LeSean McCoy | PHI | BAL |
| 3 | Adrian Peterson | MIN | at IND |
| 4 | Ray Rice | BAL | at PHI |
| 5 | DeMarco Murray | DAL | at SEA |
| 6 | C.J. Spiller | BUF | KC |
| 7 | Darren McFadden | OAK | at MIA |
| 8 | Doug Martin | TB | at NYG |
| 9 | Stevan Ridley | NE | ARI |
| 10 | Maurice Jones-Drew | JAC | HOU |
| 11 | Frank Gore | SF | DET |
| 12 | Marshawn Lynch | SEA | DAL |
| 13 | BenJarvus Green-Ellis | CIN | CLE |
| 14 | Willis McGahee | DEN | at ATL |
| 15 | Jamaal Charles | KC | at BUF |
| 16 | Michael Turner | ATL | DEN |
| 17 | Darren Sproles | NO | at CAR |
| 18 | Chris Johnson | TEN | at SD |
| 19 | Alfred Morris | AS | at STL |
| 20 | Steven Jackson | STL | WAS |
| 21 | Ahmad Bradshaw | NYG | TB |
| 22 | Donald Brown | IND | MIN |
| 23 | Reggie Bush | MIA | OAK |
| 24 | Jonathan Dwyer | PIT | NYJ |
| 25 | Trent Richardson | CLE | at CIN |
| 26 | Ryan Williams | ARI | at NE |
| 27 | Shonn Greene | NYJ | at PIT |
| 28 | Kevin Smith | DET | at SF |
| 29 | Jacquizz Rodgers | ATL | DEN |
| 30 | Mark Ingram | NO | at CAR |
| 31 | Beanie Wells | ARI | at NE |
| 32 | Ryan Mathews | SD | TEN |
| 33 | Jonathan Stewart | CAR | NO |
| 34 | DeAngelo Williams | CAR | NO |
| 35 | Peyton Hillis | KC | at BUF |
| 36 | Kendall Hunter | SF | DET |
| 37 | Ben Tate | HOU | at JAC |
| 38 | Ronnie Brown | SD | TEN |
| 39 | Knowshon Moreno | DEN | at ATL |
| 40 | Isaac Redman | PIT | NYJ |
| 41 | Pierre Thomas | NO | at CAR |
| 42 | Toby Gerhart | MIN | at IND |
| 43 | Curtis Brinkley | SD | TEN |
| 44 | Roy Helu | WAS | at STL |
| 45 | Montario Hardesty | CLE | at CIN |
| 46 | Felix Jones | DAL | at SEA |
| 47 | Mike Goodson | OAK | at MIA |
| 48 | LeGarrette Blount | SD | TEN |
| 49 | Lamar Miller | MIA | OAK |
| 50 | David Wilson | NYG | TB |
